ThemainsettingoftheshowisWisteriaLane,astreetinthefictionalAmericantownofFairviewinthefictionalEagleState.Theshowfollowsthelivesofagroupofwomen,seenthroughtheeyesoftheirdeadneighbor.Theyworkthroughdomesticstrugglesandfamilylife,whilefacingthesecrets,crimesandmysterieshiddenbehindthedoorsoftheir—atthesurface—beautifulandseeminglyperfectsuburbanneighborhood.
Theshowfeaturesanensemblecast,headedbyTeriHatcherasSusanMayer,FelicityHuffmanasLynetteScavo,MarciaCrossasBreeVandeKampandEvaLongoriaasGabrielleSolis.BrendaStrongnarratestheshowasthedeceasedMaryAliceYoung,appearingsporadicallyinflashbacksordreams.
