“What's wrong with you”的意思是你怎么了。
1、What's wrong with you在口语中是生气时才说的，包含了一些“出问题”的意思。
2、如果想要表达对身体状况关心的最合适的是what's the matter?或是are you all right?
（1）what's the matter的例句
You seem all washed out, what's the matter?
你看上去疲惫不堪，你怎么啦？
What's the matter? What's happened? What is it?
怎么了？发生什么了？
（2）are you all right的例句
Are you all right? You look dreadful
你还好吧？你看上去十分疲惫。
Are you all right? You look terrible. Are you sick?
你没事儿吧？你的脸色很难看，生病了吗？
