你的是Window操作系统吧，还需要创建ORACLE_HOME主目录及环境变量：
OraHOME.reg
Windows Registry Editor Version 5.00
[HKEY_LOCAL_MACHINE\SOFTWARE\ORACLE\KEY_OraClient10g_home1]
"NLS_LANG"="SIMPLIFIED CHINESE_CHINA.ZHS16GBK"
"ORACLE_BUNDLE_NAME"="Enterprise"
"ORACLE_GROUP_NAME"="Oracle - OraClient10g_home1"
"ORACLE_HOME"="D:\\instantclient_10_2"
"ORACLE_HOME_KEY"="SOFTWARE\\ORACLE\\KEY_OraClient10g_home1"
"ORACLE_HOME_NAME"="OraClient10g_home1"
OraEnv.reg
Windows Registry Editor Version 5.00
[HKEY_CURRENT_USER\Environment]
"LD_LIBRARY_PATH"="D:\\SmartAct\\OracleWork\\instantclient_10_2"
"NLS_LANG"="SIMPLIFIED CHINESE_CHINA.ZHS16GBK"
"ORACLE_HOME"="D:\\instantclient_10_2"
"PATH"="%PATH%;D:\\instantclient_10_2"
"SQL_PATH"="D:\\instantclient_10_2"
"TNS_ADMIN"="D:\\instantclient_10_2\\network\\admin"
分别保存成注册表文件导入再启动看看。
